Study: Aspirin Ineffective in 20 Percent of Heart Disease Patients

Corgenix Medical Corporation, developer of the AspirinWorks® Test, says study highlights importance of measuring thromboxane biomarker to determine aspirin response

A major new study conducted in Ireland found that 20 percent of patients with established heart disease were not adequately protected by aspirin. Corgenix Medical Corporation, developers of the AspirinWorks® Test for aspirin effect, said the study adds more evidence to the importance of accurately measuring aspirin response by measuring levels of the biomarker thromboxane.

“These and other major trials have established that the failure of patients to respond to the intended beneficial effect of aspirin may be a key factor in putting millions at increased risk of heart attack and stroke,” said Douglass Simpson, president and CEO of Corgenix. “The AspirinWorks Test accurately measures thromboxane levels in healthy individuals, allowing physicians to identify its potential interference with aspirin’s ability to help reduce heart attack and stroke risk.”

The Irish study conducted by the Irish Heart Foundation’s National Cardiovascular and Stroke Research Network (NCSRN) prospectively evaluated aspirin response in 700 patients with stable coronary artery disease by measuring thromboxane levels. Results showed that age, high blood pressure, weight, and alcohol consumption were significant risk factors for a poor response to aspirin. Full study results were presented at the 64th Irish Cardiac Society Annual Scientific Meeting in Killarney, Ireland.

AspirinWorks is the only US FDA-cleared test that measures the urinary biomarker 11-dehydro thromboxane B2 (11dhTxB2) to determine aspirin effect in apparently healthy individuals. The test identifies those individuals who have elevated thromboxane levels despite taking a daily aspirin dose, with studies showing up to 25 percent of individuals not seeing the expected beneficial effects of aspirin. AspirinWorks is used by thousands of physicians to test and guide treatment for hundreds of thousands of patients each year worldwide.