Health News: Why Your Great-Aunt Can’t Remember

Scientists at the Scripps Research Institute have found that brain damage in Alzheimer’s disease is linked to the overactivation of an enzyme called AMPK. When they blocked this enzyme in mice, the neurons were protected from the loss of synapses typical of the early phase of Alzheimer’s. Metformin, a drug currently on the market for treatment of type 2 diabetes, causes AMPK activation—this drug could play a role in triggering Alzheimer’s.