Health News: Two Genes Increase Risk of Developing Diabetes-Associated Kidney Disease

Researchers analyzed over two million DNA markers per person and found that changes associated with two genes (AFF3 and ERBB4) increased the risk of kidney disease. Findings were published in the journal PLoS Genetics.

Kidney disease is a common and serious complication of diabetes and is associated with a greatly increased risk of heart attack and stroke. Diabetic kidney disease is the leading cause of kidney failure requiring dialysis or kidney transplant worldwide. Up to now scientists and clinicians were aware that some patients developed kidney disease but not why this happened.

In the largest study of its kind, the investigators recruited 4,750 patients with diabetic kidney disease and almost 7,000 patients with long-standing diabetes but without kidney disease.