Health News: Step Closer to Controlling Inflammation in MS

A University of Adelaide researcher has published results that suggest a possible new mechanism to control multiple sclerosis (MS). Dr Iain Comerford earned a three-year fellowship from MS Research Australia to work on a project dedicated to understanding how specific enzymes in cells of the immune system regulate immune cell activation and migration.

“There’s already been worldwide interest in PI3Kgamma in relation to other human inflammatory disorders, such as diabetes and rheumatoid arthritis, and our study links this molecule and MS,” said Comerford.

Comerford and his colleagues have now shown that this molecule is crucial for the development of experimental autoimmune encephalitis (EAE). The team showed that a genetic alteration which knocked out that particular molecule resulted in a high resistance to the development of EAE and therefore protected against the nervous system damage typical of multiple sclerosis.